Cardiolipin IgG/IgM ELISA

  • Most sensitive and specific kit for APS screening                            ( antiphospholipid syndrome)

  • Uses authentic native human antigens used for maximum accuracy

Aesku Cardiolipin IgG/IgM ELISA kit

  • The microwells in Aesku ACL IgG/IgM are coated with human native β2 glycoprotein I (GPI) + cardiolipin. There is only 65-70 % homology between human β2 glycoprotein I & bovine β2 glycoprotein I. Thus, using human β2 glycoprotein I, maximizes the specificity of kit.

  • This is a combi kit wherein two conjugates separately for IgG & IgM are provided in the same kit and the volumes for both the conjugates are sufficient to run even 96 tests separately for IgG & IgM.

  • Kit is calibrated against HARRIS sera & standardized using Sapporo standard.

  • US FDA cleared & CE –marked product.

  • Breakable microwells & ready to use reagents.

  • Colour coded reagents for easy traceability.

  • Based on One Aesku Concept ie. Uniform incubation time (30 mins+30 mins +30 mins) and common reagents like wash buffer, sample buffer, stop solution and substrate are interchangeable.

Also available Cardiolipin IgA ELISA

ACR criteria for Antiphospholipid screening (APS)

Clinical criteria

1. Vascular thrombosis One or more clinical episodes of arterial, venous, or small vessel thrombosis, in any tissue or organ

2. Pregnancy morbidity

a) One or more unexplained deaths of a morphologically normal foetus at or beyond the 10th week of gestation, with normal foetal morphology documented by ultrasound or by direct examination of foetus, or

b) One or more premature births of a morphologically normal neonate before the 34th week of gestation because of eclampsia or severe preeclampsia or recognized features of placenta insufficiency, or

c) Three or more unexplained consecutive spontaneous abortions before the 10th week of gestation

Laboratory Criteria
  1. 1. Lupus anticoagulant present in plasma, on two or more occasions as least 12 weeks apart, detected according to guidelines of the international society on Thrombosis and Hemostatsis.

  2. Anticardiolipin antibody of IgG or IgM isotype in serum or plasma, present in medium or high titre, ie. Above 40G phospholipid units or M phospholipid units, or above the 99th percentile, on two or more occasions, at least 12 weeks apart, measured by a standardized ELISA.

  3. Anti Beta -2 Glycoprotein 1 antibody of IgG or IgM isotype, present in serum or plasma (in titre above the 99th percentile), present in two or more occasions, at least 12 weeks apart, measured by standardized ELISA.

Antiphospholipid syndrome is present if at least one of the clinical criteria and one of the laboratory criteria are met.

Related Products

Phospholipid IgG/IgM ELISA

ANA ELISA

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