Hepatitis A virus - The leading cause of acute viral hepatitis in the world
Hepatitis A is a self-limiting disease and chronic stage or other complications are rare. Infections occur early in life in areas where sanitation is poor and living conditions are crowded . The cause of hepatitis A is hepatitis A virus (HAV) non-enveloped positive strand RNA virus with a linear single strand genome, encoding for only one known serotype. The infection with HAV induces strong immunological response and elevated levels first of IgM is an important serological marker for early detection and observation of the clinical manifestation of the disease. IgG is an indicator of past infection and immunity to HAV. The serological detection of HAV IgG is also an important marker for confirming infection phase with HAV classification of the virus and identifying the source of infection.
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