Tissue transglutaminase (tTg) IgA Neoepitope ELISA
Most sensitive celiac disease detection ELISA kit
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US FDA approved tTg IgA ELISA kit coated with neoepitopes ( tTg crosslinked with deamidated gliadin peptides).
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Can be used to screen both adult and pediatric populations.
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Proved to be more sensitive than classical markers ( tTg/EMA)
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Can detect seronegative celiac disease patients
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Correlates with classical markers (tTg/EMA ) in active phase of the disease but can detect antibodies upto 15 months before tTG and DGP ( predictive marker).
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Has a better correlation with the mucosal damage ( Marsh score) in comparison to the classical markers.
Aeskulisa® tTg New generation: LOOK Closer to the truth!
Cereals contain
Gliadin
Gliadin digestion
35% Glutamine 15% proline
Undigested Gliadin
peptide
Neo-epitope:
deamidated Gliadin peptide crosslinked with tTg
The physiological processes which are mimicked by the antigens are used for the AESKULISA® tTg New Generation:
In Aesku’s special production process tTg and gliadin peptides are reacting under special conditions comparable to the “in-vivo” environment, in order to encourage both reactions: crosslinking and deamidation.
The whole reaction ensures the formation of the neo-epitope as it is encountered by the immune system “in-vivo”. These crosslinked and deaminated antigens (tTg / deamidated gliadin peptides) are then further purified and coated under special conditions to the microtiter plate.
Due to its special formulation, the AESKULISA® tTg New Generation is able to detect 3 different types of antibodies:
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Antibodies to tTG
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Antibodies to deamidated gliadin peptides
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Antobodies to neo-epitope formed by crosslinking of tTg and DGP
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